Core C: Bioinformatics

Key Personnel

  • Greg Donahue
  • Kajia Cao
  • Tony McBryan

Description

The goal of the Bioinformatics core are to assist and enhance the production and analysis of high-throughput data sets generated by the grant members, through areas including 1) sequencing data analysis; 2) microarray analysis; 3) other statistical analysis and modeling of genomic data; 4) data management. The expertise of core personnel is suited for generating creative and high quality results in tandem with each lab through these four areas. Centralization of these services through the core allows for an agile and cost-effective response to varying and specialized data.

The core has been involved in several of the project aims, including the following publications generated by this grant:
1. Rai TS, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev N, van Tuyn J, Marmorstein R, Schultz DC, Adams PD. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Molecular and Cellular Biology, 31:4107-4118(2011).
2. Kennedy AL, McBryan T, Enders GH, Johnson FB, Zhang R, Adams PD. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Division, 5(2010).
3. Johnson J, Cao K* ,Ryvkin P, Johnson FB, Wang LS. Altered gene expression in the Werner and Bloom syndromes is associated with G-quadruplex forming potential. NucleicAcidsRes, 38:1114-1122(2010). *Co-first author.

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